You can solve the first recurrence for powers of $2$. The recurrence (without the big O and with an arbitrary base case) reads
$$ T(2^k) = 2^{k-1} T(2^{k-1}) + 4^k, \quad T(2^0) = 4^0. $$
Opening the recurrence, we get
$$
T(2^k) = 4^k + 2^{k-1} \cdot 4^{k-1} + 2^{k-1+k-2} \cdot 4^{k-2} + \cdots + 2^{k-2+\cdots+1} 4^0.
$$
Denote these by $T(2^k) = \alpha_0 + \cdots + \alpha_\ell$. We have
$$
\frac{\alpha_\ell}{\alpha_{\ell-1}} = 2^{k-\ell-1}.
$$
Therefore the largest term is $\alpha_{k-1} = \alpha_{k-2}$, and the rest of the terms decrease geometrically. This shows that
$$ T(2^k) = \Theta(\alpha_{k-1}) = \Theta(2^{k-1+\cdots+1} 4^1) = \Theta(2^{k(k-1)/2}). $$
As you can see, the term $O(n^2)$ in the recurrence isn't important, and you will get similar result for any term $O(n^c)$.
One could guess that the general solution to the first recurrence (with $\lfloor n/2 \rfloor$ replacing $n/2$) is $T(n) \Theta(2^{\log_2 n(\log_2 n - 1)/2})$, and one could further guess that the second recurrence has the same solution (though that's a wilder guess). I'm not sure these guesses are correct. At the very least, the first recurrence should have the solution $T(n) = 2^{\Theta(\log^2 n)}$.