I've seen arguments for $P \ne NP$ that rely on certain intuitions about how the real world actually is, generally making the point that it "makes sense" that there exist problems which have an easily verifiable solution that's hard to find.
For example, on his blog, Scott Aaronson has a "Reasons to believe" entry which contains (among others) the following points:
8. The Self-Referential Argument. If P=NP, then by that very fact, one would on general grounds expect a proof of P=NP to be easy to find. On the other hand, if P!=NP, then one would on general grounds expect a proof of P!=NP to be difficult to find. So believing P!=NP seems to yield a more ‘consistent’ picture of mathematical reality.
9. The Philosophical Argument. If P=NP, then the world would be a profoundly different place than we usually assume it to be. There would be no special value in “creative leaps,” no fundamental gap between solving a problem and recognizing the solution once it’s found. Everyone who could appreciate a symphony would be Mozart; everyone who could follow a step-by-step argument would be Gauss; everyone who could recognize a good investment strategy would be Warren Buffett. It’s possible to put the point in Darwinian terms: if this is the sort of universe we inhabited, why wouldn’t we already have evolved to take advantage of it? (Indeed, this is an argument not only for P!=NP, but for NP-complete problems not being efficiently solvable in the physical world.)
10. The Utilitarian Argument. [$^1$] Suppose you believe P!=NP. Then there are only two possibilities, both of which are deeply gratifying: either you’re right, or else there’s a way to solve NP-complete problems in polynomial time. (I realize that I’ve given a general argument for pessimism.)
But the way I see it, once you step down from the abstractions of complexity theory and start talking about actual reality, then the concept of "polinomiality" seems to lose most of its weight and $P$ feels unimportant. Instead of supporting the idea that $P \ne NP$, these arguments could just as well merely support the idea that any $NPC$ problem has a lower-bound of $\Omega(n^k)$, for a decently sized $k$.
But I am not an expert, so I am missing some context; for example, nuanced analyses of "real" algorithms on "real sizes" of inputs. So is there something more to the robustness of this kind of arguments, or are they overblown?
$^1$ point 10 is worded in such a way that doesn't really fit my selection, but I feel that in the given context, the author did intend to conflate "solve in polynomial time" with "feasibly solve", hence why that would be gratifying.