The complexity of the number field sieve can be obtained from the expected size of the coefficients of the polynomial $f(x) = x^d + c_{d-1} x^{d-1} + \ldots + c_0$: if $c_i \le N^{\epsilon/d}$, then the expected runtime is
$$ \exp\left(\left(\left(\frac{32(1 + \epsilon)}{9}\right)^{1/3} + o(1)\right) (\log N )^{1/3} (\log \log N)^{2/3}\right),$$
or simply $L[1/3, (32(1 + \epsilon)/9)^{1/3}]$. When $\epsilon = 1$, we get $L[1/3, (64/9)^{1/3}]$ aka the GNFS, and when $\epsilon = 0$ (more accurately $o(1)$) we get the SNFS. Where does that put your example?
This requires analyzing the probability of smoothness of the numbers tested in the sieving phase, which, among other factors, depend on the size of the evaluated polynomial. The sieving process tests integers of the form
$$ F(a,b) = (a - bm) b^d f(a/b) = (a - bm)(a^d + a^{d-1}b c_{d-1} + \ldots + b^d c_0). $$
If we bound $a$ and $b$ to $M$, and $m, c_i$ to $N^{1/d}$, the size of $F(a,b)$ is bounded by $2(d + 1) M^{d+1} N^{2/d}$. In the SNFS, since both $m$ and $c_i$ are $o(1)$, the bound is much smaller, since it does not carry a $N^{1/d}$ factor anymore.
In your case, we have a mixed bag: the upper coefficients of the polynomial will be very small or 0, while the lower ones will be larger. For example, with degree $8$ and base $2^{256}$, your example results in the polynomial
$$ x^8 + c_1 x + c_0. $$
This polynomial is sparse, yes, but its expected $F(a, b)$ value size bound is not very far out from the general case: $2h M^{d+1} N^{2/d}$, where $h$ is the amount of nonzero coefficients in the polynomial. This is a constant improvement, but does not asymptotically alter the smoothness probability. So I expect your suggestion to be somewhat easier that a random prime, but not significantly so.
Since finding good polynomials seems to be an art in itself, it is hard to say when exactly the $c$ in $2^n + c$ becomes large enough to thwart the SNFS. A good rule of thumb would perhaps be to ensure that at least $c_0$ is $N^{1/d}$, by setting $c>2^{n/d}$. Since $d$ is an exponent in the size expression stated above, it will tend to be small: 1024-bit numbers are expected to have a $d$ of $6$ or $7$; 2048-bit will probably use degree $8$; and the optimal asymptotic expression for $d$ is $((3\log N)/(\log \log N))^{1/3}$, so it is very slow growing.
On a related note, the Schirokauer method for low-weight primes would not work here: it bounds the $c$ in $L[1/3, c]$ complexity of the NFS for an integer of (signed) weight $w$ as
$$ (32/9)^{1/3}((\sqrt{2}w - 2\sqrt{2} + 1)/(w - 1))^{2/3} < c < ((32/9)(2w-3)/(w-1))^{1/3}. $$
Replacing $w$ with $256$ results in the bound $1.9215 < c < 1.9217$, barely distinguishable from the GNFS.