Alginate nanoparticles

Question

I want to produce alginate nanoparticles from NaAlg. I choosed nebulizing NaAlg solution into $\ce{CaCl2}$ solution but 2% (m/v) NaAlg solution is quite viscous. What should I do to make it inviscid?

Answer 1

Dilute the feed solution tenfold, etc. Inelegant. Try solution engineering,

http://www1.lsbu.ac.uk/water/kosmos.html
Chaotropes and kosmotropes.

http://en.wikipedia.org/wiki/Theta_solvent
Add a little "poor" solvent like ethanol or acetone to ball the polymer, disrupting hydrogen bond crosslinking and reducing chain entanglement.

You want a novel solution not obvious to one skilled in the art. That qualifies it for patent protection. A large fraction of the hard answers you need already exist. They were done by other people doing other things. Accumulate bone piles of knowledge. The process for creating ceramic dislocation-pinned nickel superalloys works for Plexiglass, which "dissolves" 30 wt-% copper phthalocyanine as a dye masterbatch. So it can't be done, so what? Do it the "other" way.

Answer 2

Heating most viscous solution will decrease their viscosity. Most agar gels will liquefy when heated. Also, some polysaccharide solutions don't become viscous again when they cool down. I think alginate will become viscous, but you will have to test that out.