Let $P_2$ be the conjunction of the finite set of Peano's postulates for second-order arithmetic. These have only one full model, which is the standard model of second-order arithmetic.
We know from the incompleteness theorems that, no matter what consistent, effective extension $X$ of $P_2$ we consider, there will be some sentence $\phi_X$ in the language of arithmetic that is true in the standard model but not provable in $X$.
In particular we can let $X$ include the complete deductive system for second-order logic, the full comprehension scheme for second-order arithmetic, and the full scheme for the axiom of choice in second-order arithmetic, and any other effective axioms schemes we like.
As long as we keep $X$ consistent and effective, $P_2 \to \phi_X$ will be true, and thus valid in full semantics, but $P_2 \to \phi_X$ will not be valid in Henkin semantics. Because we let $X$ include the entire deductive apparatus of second-order logic and the comprehension and choice schemes, we don't have to worry about Henkin models of $X$ that might not satisfy these schemes.
This suggests the right way to visualize the difference between full and Henkin semantics: full semantics, in many cases, are just another way of talking about truth in a canonical "standard" model, while Henkin semantics correspond to provability instead.
As one example of how strong $X$ could be, it could include the entire set of sentences of second-order arithmetic that are provable in ZFC (this is an r.e. set of sentences, so it makes an effective axiom scheme). Then $\phi_X$ will be a true sentence of second-order arithmetic, so $P_2 \to \phi_X$ is valid in full semantics, but $\phi_X$ (and also $P_2 \to \phi_X$) will remain unprovable even if we assume as an axiom every sentence of second-order arithmetic that is provable in ZFC.
In the previous paragraph, we could replace ZFC with any sufficiently strong, consistent, effective theory $X$. There will still be a sentence $P_2 \to \phi_X$ of second order arithmetic that is valid (in full semantics) but not provable in $X$. In this way, second order logical validity (in the language of second order arithmetic with full semantics) cannot be captured in any effective theory whatsoever. In contrast, logical validity in the language first order arithmetic with first order semantics can be captured by the effective theory $V$ that just enumerates all the logically valid sentences (which just means the provable sentences, in these semantics). But $V$ is derivable even from the empty set of axioms, so in this sense every effective theory captures first-order logical validity.