It’s no different from what you’ve done before; the notation is just a bit more complicated. For instance, to show that $\sim$ is symmetric, you have to show that if $\langle a,b\rangle,\langle c,d\rangle\in\Bbb Z\times\Bbb Z$, and $\langle a,b\rangle\sim\langle c,d\rangle$, then $\langle c,d\rangle\sim\langle a,b\rangle$. Go back to the definition of $\sim$ to see what this really means.
$\langle a,b\rangle\sim\langle c,d\rangle$ means that $a-c=b-d$; this is your hypothesis.
$\langle c,d\rangle\sim\langle a,b\rangle$ means that $c-a=d-b$; this is what you need to prove in order to show that $\sim$ is symmetric. And this is easy to do: $c-a=-(a-c)\overset{*}=-(b-d)=d-b$, where the starred step uses the hypothesis that $\langle a,b\rangle\sim\langle c,d\rangle$.
Now see if you can prove reflexivity and transitivity on your own.
The equivalence class of $\langle 1,2\rangle$ is the set of all $\langle a,b\rangle$ such that $\langle 1,2\rangle\sim\langle a,b\rangle$, i.e., such that $1-a=2-b$; solve this to find what $b$ must be in terms of $a$ in order for $\langle a,b\rangle$ to be in the equivalence class.